Usage Note
Désespoir is an intense, hopeless grief. Au désespoir means 'in despair'. The verb is désespérer ('to despair, to lose hope'). The expression faire le désespoir de quelqu'un means 'to be the despair of someone' (e.g. a student who exasperates a teacher).
Examples
"Elle est tombée dans le désespoir."
Natural Translation
She fell into despair.

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