Usage Note
Main lives in a thicket of idioms: donner un coup de main is to lend a hand, fait main means handmade, and avoir la main verte is to have a green thumb. A poignée de main is a handshake, the formal greeting French professionals exchange daily.
Examples
"Donne-moi la main."
Natural Translation
Give me your hand.
Literal Translation
Give-to-me the hand.

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